|
September 2003 thru 2008
Archives |
||||
 Friday, September 5th, 2003 Toshinori Hoshi, Ph.D.
Info "Oxidative regulation of potassium channels" |
||||
Friday, September 19th, 2003 Steven
Hollenberg, M.D.
Info "Microvascular Abnormalities in Sepsis" |
||||
Friday, September 26th, 2003 Andrew Gow, Ph.D. "NO signalling: Machanisms underlying Beneficial and Negative Effects" |
||||
Friday, October 3rd, 2003 Steve Albelda, M.D.
Info "The role of PECAM in transmigration and inflammation" |
||||
Friday, October 10th, 2003
"Surfactant protein C, idiopathic interstitial pneumonia and the emerging concept of conformational lung disease" |
||||
WEDNESDAY, October 15th, 4:30 PM
"Role of iron and its proteins in ischemic pre-conditioning of the heart" |
||||
Friday, October 17th, 2003 
CHANGE OF LOCATION: "Integrins, Rac, lipid rafts and caveolin" |
||||
Friday, October 24th, 2003
“Probing pulmonary redox
functions |
||||
Friday, October 31st, 2003  Brian O’Rourke, Ph.D.
Info ”Mitochondria as biological oscillators” |
||||
Friday, November 7th, 2003
"Activation of Polycyclic Aromatic Hydrocarbons: Radical Events via Aldo-Keto Reductases" |
||||
Friday, November 14th, 2003 Alexander Verin, Ph.D. "Crosstalk between microtubules and microfilaments in the regulation of endothelial permeability" |
||||
Friday, November 21st, 2003  Shelly Phelan, Ph.D.
Info "Characterization of Peroxiredoxin 6(PRDX6) and its role in the oxidative stress response in mice" |
||||
Friday, December 5th, 2003
"Oxygen Sensing and Apoptosis during Hypoxia" |
||||
Friday, December 12th, 2003  Thomas E. DeCoursey,
Ph.D.
Info "Voltage-Gated Proton Channels in Alveolar Epithelium and Other Cells" |
||||
Friday, December 19th, 2003
"Acid Sphingomyelinase Deficiency: Pathobiology & Treatment" |
||||
Friday, December 26, 2003 and Friday, January 2, 2004 NO SEMINAR |
||||
Friday, January 9, 2004 
Phillip Ballard, M.D.
Info "Gene expression in differentiating type II cells" |
||||
Friday, January 16, 2004 David Guidot, M.D.
Info “Chronic alcohol abuse and the lung: Epidemiology, toxicology and potential new treatments” |
||||
Friday, January 23, 2004
"Manipulating the Arachidonate Cascade in Mice: What have we learned?" |
||||
Friday, January 30, 2004 
Rod Eckenhoff, Ph.D.
Info "Promiscuous Ligands and Attractive Cavities" |
||||
|
|
||||
Friday, February 13, 2004 Kenneth D. Tew, Ph.D.,
D.Sc.
Info
"Drug targeting of glutathione S-transferases and their impact upon glutathione pathways" |
||||
Friday, February 20, 2004
"Lung Surfactant |
||||
Friday, February 27, 2004 Rashmin Savani, MB,
ChB
Info
"HA! There's NO radicals in Lung Injury" |
||||
Friday, March 5, 2004 
Jahar Bhattacharya, M.D., Ph.D.
Info "Alveolar-Capillary Crosstalk" |
||||
Friday, March 12, 2004
Horace DeLisser, M.D.
Info
"The Involvement of PECAM-1 in Lung Alveolization" |
||||
Friday, March 19, 2004
“Hemodynamic etiology for the focal nature of early vascular lesions in atherosclerosis: Activation of cultured human aortic endothelial cells by disturbed flow” Using novel complex flow system, we are testing the hypothesis of the hemodynamic etiology of atherosclerotic predilection, viz that at predilected areas in vivo the presence of low shear, non-laminar flow (disturbed flow) is sufficient to induce a gene expression profile that pre-disposes the endothelium to the initiation and development of atherosclerotic lesions. Previous studies using gene expression profiling, indicate that cultured vascular endothelial cells (EC) respond to fluid mechanical forces by modulating the mRNA level of a large number of genes. However, differences between the gene arrays and the experimental conditions employed by different researchers make comparison between data sets difficult, and limit the interpretation of the results. Despite these problems, comparative analysis of recent data, obtained by both gene arrays and subtraction cloning, indicates that the transcriptional response of cultured EC to flow conditions similar to those at atherosclerosis-prone areas is distinct from that elicited by atheroprotective high shear steady laminar flow, providing a molecular basis for the focal nature of atherosclerosis. In line with recent observations in vivo, many of the genes altered by fluid mechanical forces in our in vitro model system are involved in key biological processes relevant to atherosclerosis such as inflammation, cell cycle control, apoptosis, thrombosis and oxidative stress. Overall, the gene expression profiling data are consistent with our hypothesis. Current work focuses on extending these observations to the next level, i.e., analyzing differential protein expression in these model systems and comparing to the situation in vivo. |
||||
Friday, March 26, 2004
|
||||
Friday, April 9, 2004
Jean Jiang, Ph.D.
Info "Hemichannels Formed by Connexin 43 are important for Prostaglandin E2 Production by Osteocytes in Response to Mechanical Strain" |
||||
Friday, April 16, 2004
Ivan R. Nabi, Ph.D. "Caveolae/raft-dependent endocytosis, smooth ER-mitochondria interaction and biogenesis of the multilamellar body" |
||||
Friday, April 30, 2004 
Garrett Gross, Ph.D.
Info "Mechanisms of opioid-induced cardioprotection: importance of KATP channels" |
||||
Friday, May 7, 2004
Joseph
Zasadzinski, Ph.D. "Keeping Lung Surfactants Where They Belong: SP-C and the regulation of monolayer viscosity" |
||||
Friday, May 14, 2004 
Roberta
Colman, Ph.D.
Info "Exploring Subunit Interactions and Substrate Specificity in Glutathione S-Transferases" |
||||
Friday, May 21, 2004 Constance Barazzone,
M.D.
Info "Physiopathological and molecular mechanisms of alveolar cell death during hyperoxia: apoptosis versus necrosis" |
||||
Friday, May 28, 2004
Melpo Christifidou-Solomidou, Ph.D.
Info
"Nutritional Approaches to Acute Lung Injury" |
||||
Friday, June 11, 2004
email Susan Turbitt for more information. |
||||
Friday, June 18, 2004 
Norma Andrews, Ph.D.
Info
"Regulation of lysosomal exocytosis by synaptotagmin VII" |
||||
Friday, June 25, 2004
|
||||
|
September 2004 thru June 2005 Archives |
||||
Friday, September 3rd, 2004 
George Perdrizet, M.D., Ph.D.
Info "Clinical implications of the cell stress response" |
||||
Friday, September 10th, 2004
"Stem cells of the tracheobronchial epithelium" |
||||
Friday, September 17th, 2004 Peter Davies, Ph.D. Info
|
||||
 Friday, September 24th,
2004Matthias Ochs, M.D. "Measuring the lung structure. Stereological aspects of the pulmonary surfactant system" |
||||
Thursday, Sept 30th, 3:30 Jay Dean: "Aviator vs. the environment: areomedical research and practices during World War II" and Friday, October 1st, 12:15
Jay B. Dean, Ph.D.
Info
"Hyperoxia and central CO2-chemoreception: does oxidative stress disrupt central respiratory control?" |
||||
Friday, October 8th, 2004 Bruce Spiess, M.D.
Info
"Advances in decompression illness treatment with perfluorocarbon emulsions" |
||||
Friday, October 15th, 2004 Mary Williams, Ph.D. "Gene targeting of TI α, a type I cell gene, results in respiratory failure at birth" |
||||
Friday, October 22nd, 2004 
Claudette St. Croix, Ph.D.
Info “Intracellular zinc homeostasis and pulmonary vascular reactivity” |
||||
Friday, October 29th, 2004 Gina Schatteman, Ph.D.
Info
"Stem cell-monocyte interactions in vascular growth"
|
||||
|
Robert Mason, M.D.
Info "Regulation of lipogenesisin alveolar type II cells" |
||||
Friday, November 19th, 2004 Yassine Amrani, Ph.D.
Info "Calcium handling in airway smooth muscle: modulation and therapeutic implications for the treatment of asthma" |
||||
|
Friday, December 3rd, 2004 Gang Zheng, Ph.D. "Development of Molecular Imaging Probes and Therapeutic Agents" |
||||
Friday, December 10th, 2004
Ilya
Fishbein, Ph.D. Vascular Gene Delivery and Therapies |
||||
Friday, December 17th, 2004 
Daniel P. Schuster, M.D.
Info
"Molecular imaging of acute lung injury" |
||||
 Friday, January 7th,
2005
Randal J. Kaufman, Ph.D.
Info
Info "The biochemicalbasis for ERAD and the unfolded protein response: role in health and disease" |
||||
Friday, January 14th, 2005
Marilyn Merker, Ph.D.
Info "Impact of hyperoxia on pulmonary endothelial cell redox activity"
|
||||
Friday, January 21st, 2005 
William Aird, M.D.
Info "Spatial and temporal dynamics of the endothelium" |
||||
January 28th, 2005
NO SEMINAR SECHEDULED |
||||
Friday, February 4th, 2005
"Role of the endothelial surface layer in leukocyte-endothelium adhesion" |
||||
|
Washington University/St. Louis Children's Hospital Division of newborn Medicine Host: Aron Fisher, M.D.
"Molecular epidemiology of mutations in surfactant associated genes" |
||||
|
Friday, February 18th, 2005
Gary Koretzky, M.D., Ph.D.
Info
Info
University of Pennsylvania Biomedical Graduate Studies Host: Tatyana Milovanova, M.D., Ph.D.
"The role of adapter proteins and enzymes in hematopoietic cell development and function" |
||||
Friday, February 25th, 2005 
Michael K. Gilson, Ph.D.
Info "Modeling of molecular recognition" |
||||
|
Asma Nusrat, M.D.
Info
CV
"Apical Junctional Complex: Gatekeeper of the epithelial paracellular pathway" |
||||
|
CANCELLED (rescheduled for 5/20/05)
Anil K. Jaiswal, Ph.D.
Info
"Nrf2 signaling in antioxidant-induction of gene expression" |
||||
|
Friday, March 18th, 2005
Ursula Jakob, Ph.D.
Info
"Redox Switches: A Novel Way to Regulate Protein Activity" |
||||
|
Friday, March 25th, 2005
Radu V. Stan, M.D. Info Dartmouth Medical School Department of Microbiology and Immunology Host: Vladimir Muzykantov, M.D., Ph.D.
"PV1 is necessary and sufficient for the formation of the endothelial stomatal and fenestral diaphragms" |
||||
|
Friday, April 1st, 2005
No Seminar Scheduled |
||||
|
Brian Bahnson, Ph.D. Info University of Delaware Department of Chemistry & Biology Host: Aron B. Fisher, M.D.
"Correlating Structure, Function and Interfacial Activation in PLA2" |
||||
|
Volker Haase, M.D. info University of Pennsylvania Department of Medicine, Renal Division Host: Aron B. Fisher, M.D. "Differential function of hypoxia inducible factors in health and disease" |
||||
|
Victoria Bolotina, Ph.D. info
Boston University Host: Aron B. Fisher, M.D.
"The mysteries of the store-operated calcium influx pathway: from ion channels to cell function." |
||||
|
Joshua Hare, M.D. info info CV Johns Hopkins University Dept of Cardiovascular Medicine Host: Andrew Gow, Ph.D.
"Nitroso-Redox imblanace in the cardiovascular system" |
||||
|
Pamela L. Zeitlin, M.D., Ph.D.
Info
"Cystic fibrosis: new therapies" |
||||
|
Friday, May 13, 2005 (rescheduled for 10/07/05) |
||||
|
Friday, May 20, 2005 NO SEMINAR |
||||
|
Mark Mattson, Ph.D. info National Institute of Health Host: Madesh Muniswamy, Ph.D.
"Cellular and Molecular Mechanisms that Protect the Brain Against Adversity" |
||||
|
Brigid Hogan, Ph.D. info Duke University
Department of Cell Biology
"Genetic Regulation of Embryonic Lung Development" |
||||
|
NO SEMINAR |
||||
|
Marie-Odile Parat Salvado, Pharm.D., Ph.D. info Cleveland Clinic Foundation
Anesthesiology Research " Endothelial Cell Migration and Angiogenesis:the Paradoxical Role of Caveolin-1" |
||||
|
(Respiration Research Retreat 2005) Guest Speakers are:
National Institute for Health Laboratory of Pulmonary Pathobiology Chief, Laboratory of Respiratory Biology "Genetic Susceptibility to acute lung injury: usefulness of animal models"
Chief,
Pulmonary, Critical Care and Sleep Medicine "Macrophage gene expression in lung and systemic inflammation: A transcriptional paradigm" |
||||
|
September 2005 thru Present Archives |
||||
|
Tim D. Oury, M.D., Ph.D. info CV University of Pittsburg
Department of Pathology
"Oxidants and proteases: Synergism in interstitial lung disease" |
||||
|
James Stone, M.D., Ph.D. info CV Harvard Medical School
Department of Pathology
"Signal Transduction in Endothelial Cells Stimulated by Physiologic Levels of Hydrogen Peroxide" |
||||
|
University of Iowa
Free Radical and Radiation Biology
"Quantitative Redox Biology: Antioxidant Enzymes and Peroxide Tone" |
||||
|
Martin Schwartz, Ph.D. info University of Virginia
Depts. of Microbiology and Biomedical Engineering
"Integrins and Rho family GTPases in the regulation of cell-cell junctions" |
||||
|
Friday, October 7, 2005
University of Washington Pulmonary & Critical Care Medicine Host: Rashman Savani, M.D. and Horace Delisser, M.D.
"Insights into Alveolar Septation" |
||||
|
Friday, October 14, 2005 CANCELLED |
||||
|
Friday, October 21, 2005
Craig N. Giroux, Ph.D. info CV Wayne State University Institute for Environmental Health Sciences Host: Aron B. Fisher, M.D.
"Exploring the genetic network that underlies cellular responses to oxidative stress" |
||||
|
Friday, October 28, 2005
Richard Minshall, Ph.D. Info Info CV University of Illinois at Chicago Department of Pharmacology Host: Vladimir Muzykantov, M.D., Ph. D.
"Activation of Caveolae-mediated Transendothelial Transport: Role of Gbg, Src, Caveolin-1, and Dynamin-2" |
||||
|
Friday, November 4, 2005
Anil K. Jaiswal, Ph.D.
Info
CV
"Nrf2 signaling in antioxidant-induction of gene expression" |
||||
|
Friday, November 11, 2005
Andreas Guenther, M.D.
info
CV
Biosketch
"Prevention of Lung Fibrosis by Inhalative Treatment with
Anticoagulant or Fibrinolytic Compounds" |
||||
|
Friday, November 18, 2005
Roger O'Neil, Ph.D.
info
CV
Department of Integrative Biology & Pharmacollogy
"Vanilloid-receptor TRP calcium-permeable channels (TRPVs): Mechanosensory functions in polarized cells" |
||||
|
Friday, November 25, 2005 NO SEMINAR
HAPPY THANKSGIVING! |
||||
|
Wednesday, November 30, 2005 4:30 p.m.
Sarah Gebb, Ph.D.
info
CV
Division of Pulmonary Sciences & Critical Care Medicine
"Fetal Oxygen tension and lung branching morphogenesis" |
||||
|
Friday, December 2, 2005
Ivan McMurtry, Ph.D. info CV CV University of Colorado Health Sciences Center
Division of Pulmonary Sciences & Critical Care Medicine
"RhoA/Rho Kinase-Mediated Vasoconstriction in Rodent Models of Pulmonary Hypertension" |
||||
|
Friday, December 9, 2005
Andrew
Tsourkas, Ph.D.
info
CV
Department of Bioengineering
"Molecular probes for the non-invasive imaging of disease" |
||||
|
Friday, December 16, 2005
Michael Goligorsky, M.D., Ph.D. info CV New York Medical College Department of Nephrology Host: Vladimir Muzykantov, M.D., Ph.D.
"Premature Senescence of Endothelial Cells: Methusaleh's Dilemma" |
||||
|
Friday, December 23, 2005
Shampa Chatterjee, Ph.D. info Biosketch University of Pennsylvania Institute for Environmental Medicine Host: Aron B. Fisher, M.D. "KATP channel, shear stress and the pulmonary vasculature" |
||||
|
Friday, December 30, 2005
NO SEMINAR SCHEDULED Happy New Year! |
||||
|
Friday, January 6, 2006
Randen Patterson, Ph.D. CV Department of Biology Pennsylvania State University Host: Madesh Muniswamy, Ph.D.
"TRPC Channels: Decoding the Function of Primary Amino Acid Sequences" |
||||
|
Friday, January 13, 2006
Pamela Davis, M.D., Ph.D. info CV Case Western Reserve University Department of Pediatric Pulmonology Host: Vladimir Muzykantov, M.D., Ph.D.
"Think Small: Nanoparticles for Airway Gene Transfer " |
||||
|
Friday, January 20, 2006
Iraimoudi Ayene, Ph.D. info CV Department of Radiation Oncology University of Pennsylvania Host: Aron B. Fisher, M.D. "Oxidative Pentose Cycle in Ku Protein Thiol Homeostasis" |
||||
|
Friday, January 27, 2006
Clifford Deutschman, M.S., M.D. info CV BioSketch
| ||||
Michael Beers, M.D.
Mottie (Mordechai)
Chevion, Ph.D.
Trevor Penning,
Ph.D.
Navdeep Chandel, Ph.D.
Colin Funk, Ph.D.
Harry
Ischiropoulos, Ph.D.
Avinash
Chander, Ph.D.
David A. Dean, Ph.D.
Douglas
Goetz, Ph.D.
Susan Reynolds, Ph.D.
Friday,
November 5th,
2004
Herbert H. Lipowsky
Aaron Hamvas, M.D.
Steven
Kleeberger, Ph.D.
John
Christman, M.D.
